The fight to find effective, long-lasting treatments for cancer has led many researchers to consider protein degrading entities. Recent developments in PROteolysis TArgeting Chimeras (PROTACs) have signified their potential as possible cancer therapies. PROTACs are small molecule, protein degraders that function by hijacking the built-in Ubiquitin-Proteasome pathway. This review mainly focuses on the general design and functioning of PROTACs as well as current advancements in the development of PROTACs as anticancer therapies. Particular emphasis is given to PROTACs designed against various (...) types of Leukemia/Blood malignancies. (shrink)

La posición de Vico sobre el antiguo Egipto tenía origen en el debate seicentesco sobre la supremacía del saber egipcio . En línea con la historiografía protestante, Vico muestra que los egipcios habían desarrollado sólo un saber civil y que sus conocimientos filosóficos eran aquéllos aprendidos de los hebreos.PALABRAS CLAVE: Vico, hebreos, egipcios, sabiduría antigua, historiografía protestante.Vico’s attitude towards the ancient Egypt had its roots in the Seventeenth Century debate on the supremacy of Egyptian wisdom . In agreement with protestant (...) historiography, Vico shows that Egyptians had only developed a kind of civil knowledge, whereas their philosophical knowledge had been received from Hebrews.KEYWORDS: Vico, Hebrews, Egyptians, ancient wisdom, protestant historiography. (shrink)

This paper employs the interpretative lens provided by stakeholder theory to garner novel insights for research and managerial practices within the framework of high-reliable organizations (HROs). It proposes an interpretative matrix for analyzing and explaining how stakeholders’ behaviors and interactions can transition from a “strategic” to a “responsibility” approach in the context of risk management. The paper adopts a qualitative methodology based on a case study of the Italian Civil Protection—an HRO—during the COVID-19 pandemic. Through the analysis of institutional sources (...) and reports, we apply two theoretical frameworks to examine how the organization's engagement strategy changed in response to an unexpected event. This case serves to illuminate the main implications and practical applications of shared conceptual reflections. The principal implications are traced in terms of theory, practice, and policy, focusing on the joint examination of organizational reliability and stakeholder engagement theory, the potential utility of the proposed case study, and the feasible policy actions. The main limitations of this study lie in the purely qualitative methodology employed, the nature of the organization analyzed, and the territorial scope of the study. Future works will address an empirical investigation of the theoretical relations uncovered herein, as well as the expansion of the spectrum of analysis (e.g., private organizations) and a cross-country widening of the level of analysis. (shrink)

Background: Psychological distress is common among patients with cancer, with severe consequences on their quality of life. Anxiety and depression are the most common clinical presentation of psychological distress in cancer patients, but in some cases cancer may represent a traumatic event resulting in posttraumatic stress disorder. Currently, Eye Movement Desensitization and Reprocessing therapy is considered an evidence-based treatment for PTSD, but recent studies also showed its effectiveness for anxiety and depression. The aim of the present systematic review is to (...) summarize the current literature on the effect of EMDR on cancer-related psychological distress.Methods: A literature search was conducted for peer-reviewed articles about “EMDR” and “cancer patients” in the following electronic databases: PubMed, MEDLINE, Science Direct, Google Scholar, and Cochrane library.Results: Our search identified 7 studies in which EMDR was used with a total of 140 cancer patients. The psychiatric diagnosis was PTSD in 3 studies. Otherwise, the diagnosis concerned the anxious and depressive disorder spectrum. Overall, EMDR treatment schedules used were highly heterogeneous, with a different number of sessions and a different duration of therapy. However, across all studies analyzed EMDR therapy was judged to be adequate in reducing symptoms of psychological distress in this population.Conclusions: According to the results of our analysis, the level of evidence regarding EMDR efficacy in cancer patients is limited by the scarcity of studies and their low methodological quality. Although better quality research is needed, available data suggest that EMDR could be a promising treatment for psychological distress in patients with cancer. (shrink)

The paper focuses on Epicurus’ Letter to Pythocles 91; more specifically, the article provides a detailed philological analysis of the presence in the text of οὐχ ἅμα after ἢ μικρῷ ἔλαττον ἢ τηλικοῦτον. The examination of this expression contributes to better understanding Epicurus’ position on the (very debated) topic of the size of the sun.

L’anno appena trascorso è stato dimenticabile (per ovvie ragioni) e i filosofi politici hanno una ragione in più per dimenticarlo data la prematura scomparsa di Gerald Gaus. Tuttavia, essi potrebbero forse trovare una qualche consolazione nel fatto che il 2020 ha visto la pubblicazione di due notevoli opere dedicate alla loro disciplina: 'Utopohobia', di David Estlund e 'What is Political Philosophy?', di Charles Larmore. In questo saggio, dopo aver offerto una sintesi criminalmente breve del nucleo argomentativo dei due volumi, li (...) metterò in dialogo, usando le risorse dell'uno per interrogare e problematizzare alcune tesi dell'altro (e viceversa). (shrink)

Le contrôle de constitutionnalité, dont la magistrature parlementaire de l’Ancien Régime revendiquait le plein droit, n’était pas fondé uniquement sur les lois fondamentales du royaume, mais sur l’ensemble des principes (« les maximes ») tirés de la « Tradition ». Cette dernière était composée en premier lieu par le droit divin et le droit naturel, c’est-à-dire par des systèmes juridiques qui nécessitaient, tous les deux, une interprétation juridictionnelle ‘sapientiale’. Cette activité interprétative était ‘révélatrice’ d’un corpus de valeurs métaphysiques à laquelle (...) seule la Scientia Juris des magistrats pouvait puiser. Mais dans la sphère de la Tradition juridique rentraient aussi le « dépôt légal », c’est-à-dire l’ensemble de toutes les lois, même des lois ainsi dites « ordinaires », c’est-à-dire celles qui avaient été produites par la simple manifestation de volonté souveraine d’un roi prédécesseur « car tel avait été son plaisir » (moderne formulation du brocarde de droit romain : « quidquid principi placuit legis habet vigorem »). Ainsi la juridiction parlementaire donnait lieu à un jugement de constitutionnalité qui était normalement exercé de manière très flexible par le corps de la magistrature, dépendant des circonstances et des intérêts politiques momentanés des situations juridiques qu’elle voulait protéger. La hiérarchie des normes était ainsi un formidable instrument de protection de cet ordre juridique dont les legum doctores se sentaient les tuteurs. Elle était, donc, directement liée au gouvernement politique des juges. (shrink)

Découvert et transcrit par Francesco Saverio Nisio qui en a complété les références bibliographiques, ce texte, proposé en 1880 par le jeune Lucien Lévy à la Revue des études juives qui venait de se créer, et resté inédit depuis, met l’accent sur « l’exactitude et la profondeur des observations » psychologiques de Spinoza, « grand métaphysicien », c’est-à-dire « grand artiste », dans l’ Éthique.

1. La formazione del pensiero filosofico dalle origini a Platone, VI-IV a.C. -- 2. Filosofia, cultura, scuole tra Aristotele e Augusto, IV-II secolo a.C. -- 3. Pensiero, culture e concezioni religiose, II secolo a.C.-II secolo d.C. -- 4. Cultura, filosofia, politica e religiosità, II-VI secolo d.C.

Dalla "Filosofia morale."--Ragionamento al signor conte Gregorio Casati sopra un libro franzese.--Dai "Paradossi."--Della forza de' corpi che chiamano viva.--Della forza attrattiva delle idee.--Frammenti varj sopra la forza attrattiva delle cose che non sono.

Quaestio, Volume 20, Issue, Page 257-288, January 2020.

Zubiri’s thought can be qualified as an attempt to reconsider the assumptions and contents of the history of metaphysics from a new perspective. In almost all his writings, Zubiri targets the tradition of Western metaphysics and its fundamental concepts from heterogeneous perspectives and with different methods. Among his mature writings there is one that is exemplary in this regard: Los problemas fundamentales de la metafisíca occidental (1969-1970). This paper examines the peculiar definition of metaphysics that Zubiri formulates in this work, (...) paying particular attention to the transcensus of the first science, to the notion of the transcendental and, finally, to the distinction, elaborated by Zubiri, between the object of metaphysics and the things that constitute the object of ordinary knowledge. (shrink)

Riassunto: Questo lavoro mira a un confronto tra la psicologia morale di Friedrich Wilhelm Nietzsche e l’approccio socio-intuizionista al giudizio morale proposto da Jonathan Haidt. Questo confronto metterà in luce somiglianze notevoli tra i due modelli. Il lavoro intende inoltre chiarire quali implicazioni Nietzsche trae dalla sua descrizione della psicologia umana e quali cambiamenti di prospettiva egli esorta a operare rispetto alla comprensione di noi stessi come “esseri morali”. Parole chiave: Giudizio morale; Sviluppo morale; Intuizionismo; Friedrich Wilhelm Nietzsche; Jonathan Haidt (...) The Dawn of Moral Psychology. Nietzsche’s Moral Psychology and some Recent Empirical Investigations: Comparing Nietzsche’s moral psychology and the social intuitionist approach to moral judgment proposed by Jonathan Haidt, this paper reveals remarkable similarities between the two models. It also clarifies what implications Nietzsche drew from his description of human psychology and the perspective changes these entail for understanding ourselves as “moral beings”. Keywords: Moral Judgment; Moral Development; Intuitionism; Friedrich Wilhelm Nietzsche; Jonathan Haidt. (shrink)

The desire of knowledge constitutes, as it is well known, the opening ‘theme’ of Aristotle’s Metaphysics. This article focuses on the figure of Dominic of Flanders, one of the commentators of Aristotle’s Metaphysics who much developed this topic. Dominicus deals with it in the second question of the first book of his commentary. What makes the interest of Dominic’s account is its originality, in so far as, according to him, the beginning of Aristotle’s Metaphysics aims to stress the very primacy (...) of Metaphsyics, and not only, the primacy of science in general. In this sense, the desire of knowledge constitutes for Dominic the most efficacious argument for the primacy of Metaphsyics. However, this is possible only if the desiderium sciendi is related to two other principles: the first is that desirability entails perfection, and the second is that the desirability of an object depends on its intelligibility. (shrink)